Despite their best efforts, the Quaids couldn't make it work.
Dennis Quaid's wife, Kimberly Quaid, filed a divorce petition in L.A. Tuesday.
"After careful consideration, we have decided to end our 12-year marriage," the exes told TMZ in a joint statement. "The decision was made amicably and with mutual respect toward one another."
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The Quaids plan to share custody of their 8-year-old twins, son Thomas and daughter Zoe. "We will always remain great friends and devoted partners in raising our children," said the 62-year-old actor, who was filming Crackle's "The Art of More" in Vancouver when Kimberly filed the documents.
TMZ reports most of their assets have already been divided.
Kimberly, a real estate agent, first filed for divorce in March 2012, claiming that the marriage had become "insupportable because of discord or conflict of personalities." Two months later, however, she withdrew the divorce papers and asked a judge to dismiss the previous petition. The pair split again in October, and the following month, Dennis filed for divorce. He asked for joint legal and physical custody of the children and offered to pay spousal support to Kimberly.
Dennis and Kimberly reconciled in the spring of 2013.
Kimberly is Dennis' third wife. He was previously married to actresses P.J. Soles and Meg Ryan.