It's been over five years since the Sixers have won a game against the Raptors at Scotiabank Arena.
On top of that, Kawhi Leonard is a perfect 11-0 against the Sixers, averaging 15.6 points (49.6 percent shooting) and 7.7 rebounds.
Here are the essentials for tonight's game:
When: 8 p.m. ET with Sixers Pregame Live at 7:30 p.m.
Where: Scotiabank Arena
Broadcast: NBC Sports Philadelphia
Live stream: NBCSportsPhiladelphia.com and the NBC Sports MyTeams app
And here are three storylines to watch for tonight's matchup.
Royalty of the East
The Raptors (20-5) sit atop the Eastern Conference with the best record in the NBA, having lost just five games this season. Their field goal percentage (49.2) is second only to Golden State, and they average 116.6 points. Their first matchup on Oct. 30 was an indicator that the Raptors were well above the Sixers, but it was also against a team that hadn't yet acquired Jimmy Butler.
Brett Brown joked that he had "selective amnesia" when it came to remembering their last game against Toronto, but said this one will be an "early barometer" of where they are as a team.
More for JoJo
Despite putting up MVP numbers to start the season, Embiid said the past few games he hasn't felt like he's been aggressive enough, and hopes that will change in Toronto. He also pointed to his shooting percentage going down, which it has, but not drastically. He's shot 41.3 percent over his last three games, about six percent down from his career average (His three-point numbers over the past three games are a different story at 12.5 percent).
Embiid also said he's still figuring out the new floor spacing with Butler. With the energy expected to be pumping in Scotiabank Arena on Wednesday night, this could be one of those games Embiid gets up for.
Will the headbands follow Butler and Ben Simmons on the road? And if they do, will they be white? Furthermore, what type of bet will they make before tonight's game? Last game, Butler and Simmons made bets on who would have more blocks and steals - Simmons won with two. Butler said he would discuss on the plane with Simmons what they might wager against the Raptors.
Bets and headbands, it might sound silly, but it's clearly working for these two.
Click here to download the new MyTeams App by NBC Sports! Receive comprehensive coverage of your teams and stream the Flyers, Sixers and Phillies games easily on your device.