And then there's the former Eagle on the Bills who is a little less famous.
It was cataclysmic when Chip Kelly traded LeSean McCoy to the Bills. It was historic when Howie Roseman traded Jordan Matthews to the Bills.
Jordan Poyer's journey from Philly to Buffalo is a little bit different and a whole lot less well-known. But the one-time Eagles draft pick has become an important part of Sean McDermott's defense.
Poyer, who signed as a free agent with the Bills this past offseason, was the second of three Eagles seventh-round picks in 2013. He made the team as a long-shot cornerback and played in three games as a rookie before getting released on Oct. 19 so the Eagles could sign running back Matthew Tucker off their practice squad.
The Eagles hoped to land Poyer on the practice squad, but the Browns claimed him, and he wound up spending four years in Cleveland, playing in 45 games and starting four last year with two interceptions before his season ended with a horrific injury - a lacerated kidney.
He finally escaped Cleveland this spring, signing a four-year, $13 million deal with the Bills that includes $7.4 million in guaranteed money and he goes into the regular season as the Bills' starting free safety.
Not bad for the 46th defensive back taken in the 2013 draft.
"Being in Philadelphia, starting my career here was huge," Poyer said Thursday night after the Eagles-Bills preseason game at the Linc.
"I'm in Year 5 now and you never know what would have happened if I didn't start out here, start my career here. It was a big part of my foundation, learning the NFL game."
The Browns went 12-47 while Poyer was in Cleveland, and he played under three head coaches and four defensive coordinators during his stay with Cleveland.
"It was a challenge," he said, shaking his head. "We all play this game to win football games. That's the name of the business, the name of the game. That's why we start playing when we're little. Anytime you're not winning it's always tough.
"I'm trying to put that time of my life behind me now, I'm here in Buffalo now and happy here."
But the one good thing that happened to Poyer in Cleveland was the switch from corner to safety.
"It's a lot different and it took some time," he said. "But I feel good about it, felt good about making the switch. Took it and ran with it and learned the position.
"It's still a new position, and I still have a lot of things to learn, but I feel like it was good for me. Really one of the best things to happen to my career."
In Buffalo, Poyer's head coach, McDermott, and defensive coordinator, Leslie Frazier, are both former Eagles secondary coaches. Nobody has a better feel for the secondary than McDermott, who played in the same secondary as Mike Tomlin at William & Mary and worked under Jim Johnson for a decade in Philly before going to a Super Bowl with Ron Rivera in Carolina.
"It's a great situation for me with Sean and Leslie," Poyer said. "Sean coaches us every day, helps us get better, helps get the whole football team better. I learn something from him every day."
Poyer has played in more games than 24 of the defensive backs drafted ahead of him in 2013 and in more games than all but five of the 47 other seventh-round picks that year.
The only defensive back the Eagles have taken in the seventh round the last 50 years who's played in more career games is Kurt Coleman, another player who revived his career under McDermott.
To go from seventh-round pick to $7½ million in guaranteed money is quite a story, but Poyer is so grounded he said he doesn't really think about the big picture of his career arc.
"During the season, you're moving so fast you don't really have time to sit back and look at what you've accomplished or how far you've come," he said.
"At the end of the season or at the end of my career I'll look back on it and soak in everything that I had to go through and got to where I am now, but right now, I'm just focused on getting ready (for opening day).
"Philly gave me a good opportunity, made a lot of good friends here and now excited to be here in Buffalo."