Ben Simmons has been listed as questionable for Wednesday's game against the Wizards after suffering a right ankle sprain on Monday playing the Cavs.
The questionable status means a 50 percent chance a player will be available.
Simmons on Monday left for the locker room with five minutes to play. X-rays taken after the game were negative. He will be reevaluated prior to the game on Wednesday.
Complete coverage of the Philadelphia 76ers and their rivals in the NBA from NBC Sports Philadelphia.
The question for the Sixers is not only will Simmons play, but will Joel Embiid, as well? The big man has yet to be cleared for back-to-backs and the Sixers face the Celtics the following night in Boston.
The Sixers lost their first game to the Wizards, 120-115, on opening night. That was with 28 points, eight assists and five rebounds from John Wall, though, who is sidelined because of a left knee injury.
Whether these injuries and the back-to-back impact who plays on Wednesday remains to be seen.
In the meantime, the Sixers who are cleared to go will be looking for a bounce-back win after a 23-point loss to the Cavaliers (see story).
"I hate losing," Emiid said after the game. "But I think that's actually good that we got our ass kicked so we can go back, learn, and know that we can't take any days off, we can't feel comfortable. We've just got to keep working hard and keep getting better."