Derrick Gunn makes his picks for Week 8 of the NFL season.
49ers at Eagles (1 p.m. on FOX)
Losing both future Hall of Famer LT Jason Peters and LB Jordan Hicks for the season are big blows, but the Eagles have become used to the next-man-up mentality. Each week, the legend of Carson Wentz continues to grow. In comes a 49ers squad still in search of its first win of the year. Prior to getting blown out by Dallas, the Niners had set an NFL record for losing five consecutive games by three points or less. Last Sunday, the Cowboys attacked a porous Niners' run defense (29th, allowing 134.6 yards per game) by running the ball 43 times for 265 yards, including 26 by Dak Prescott.
The Eagles must do the same ground and pound and put the Niners away early. San Fran rookie QB C.J. Beathard has potential, but he's not ready for what Jim Schwartz will throw at him. It should be an interesting game for at least a half, but the team with the best record in the league should eventually pull away.
Complete coverage of the Philadelphia Eagles and their NFL rivals from NBC Sports Philadelphia.
Pick: Eagles 31, Niners 10
Vikings at Browns in London (9:30 a.m. on NFL Network)
This matchup just isn't fair. The Vikes' fourth-ranked defense against the Browns' inept offense. Cleveland could put QBs DeShone Kizer and Kevin Hogan in at the same time and it still wouldn't help.
Raiders at Bills (1 p.m. on CBS)
The Raiders may have saved their season with a win over KC but now they have to go into the Bills' domain and do what no one has done this season: Beat Buffalo at home (3-0). Head coach Sean McDermott has his guys believing in themselves. I believe the Bills stay perfect at home.
Colts at Bengals (1 p.m. on CBS)
It wasn't that long ago that both squads were consistent playoff teams. Now, they're both hard to watch. The Colts are winless on the road this season. That won't change in Cincy.
Chargers at Patriots (1 p.m. on CBS)
After losing their first four, the Chargers have won three straight. The Pats have also won three in a row. Philip Rivers vs. Tom Brady should be fun to watch. Surprisingly, the Pats' home record is 2-2, but the Chargers' streak ends in Foxboro.
Bears at Saints (1 p.m. on FOX)
Get this. Bears rookie QB Mitchell Trubisky has thrown 23 passes in his last two games, completing just 12, and the Bears have won two in a row. Drew Brees throws that many passes in a half, plus the Saints have won four straight. Trubisky and Chi-town will go down in the Bayou.
Falcons at Jets (1 p.m. on FOX)
At the beginning of the season, this looked like a Falcons' route. But my, how times have changed. The Falcons can't score and the Jets are winning games no one expected them to. This is the fourth straight game the Falcons play an AFC East foe (0-3 so far). I look for the Dirty Birds to slip out of town with a dirty win.
Panthers at Buccaneers (1 p.m. on FOX)
Both teams have been disappointments as of late. There's still time to right their wrongs but it has to start now. In this NFC South matchup, I like the Panthers' third-ranked D more than the Bucs 30th-ranked D.
Texans at Seahawks (4:05 p.m. on CBS)
Texans rookie QB DeShaun Watson has played well this season. He will be thoroughly tested by the Seahawks' stout defense. The 'Hawks are 2-0 at home, plus the CenturyLink Field 12th man will be too much for Watson and the Texans to overcome.
Cowboys at Redskins (4:25 p.m. on FOX)
Both the 'Boys and 'Skins are trying to stay within striking distance of the Eagles. Dallas is getting healthy on defense and their run game was hitting on all cylinders last Sunday vs. the Niners. The 'Skins need to show they've shaken off a Monday night loss to the Eagles. I don't think they can.
Steelers at Lions (8:30 p.m. Sunday Night on NBC)
The Lions are coming off a bye week but their offense has injuries all over the place, including QB Matt Stafford, who's played through hamstring and ankle injuries. The Steelers' second-ranked defense has been tough to score on and the Killer B's on offense have been swarming. The Lions are about to get stung.
Broncos at Chiefs (8:30 p.m. Monday night on ESPN)
It looked like KC would run away with the AFC West, but a two-game slide brought them back to Earth. The Broncos' two-game slide looks worse, because they lost to the Giants and Chargers, scoring a grand total of 10 points in those two games. Denver picked a bad time to go into an offensive drought with the Chiefs having so many explosive weapons.