Brangelina is history.
Citing irreconcilable differences, Angelina Jolie has filed for divorce from husband Brad Pitt after two years.
Jolie's lawyer Robert Offer told The Associated Press the decision was made "for the health of the family."
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In a statement released to People Magazine, Pitt also said his focus is on the "well-being of our kids."
"I am very saddened by this, but what matters most now is the well-being of our kids," he said in the statement. "I kindly ask the press to give them the space they deserve during this challenging time."
The couple have six children together and married on August. 14, 2014, after a 12-year relationship. They first worked together on the 2004 set of "Mr. and Mrs. Smith."
The stars separated on Sept. 15, according to court documents, less than a month after their two-year wedding anniversary. The documents listed the date of the filing as Monday.
In a statement released to E! News, Jolie's manager Geyer Kosinski said her focus was now on the children. "Angelina will always do what’s in the best interest to protect her children. She appreciates everyone's understanding of their need for privacy at this time."
Pitt was previously married to actress Jennifer Aniston in 2000, divorcing in 2005. This was the third marriage for Jolie, having previously been wed to Jonny Lee Miller in 1996 and Billy Bob Thornton in 2000.
The divorce was first reported by TMZ.
In 2014 the couple wed privately in the French hamlet of Correns in Provence with their children serving as ring bearers and throwing flower petals.
The pair adopted children from Cambodia, Vietnam and Ethiopia. And they sought to direct the glare of their celebrity toward other causes. Jolie, a goodwill ambassador for the United Nations, became an outspoken voice for refugees and various causes in Africa, as well as for breast cancer treatment after undergoing a double mastectomy in 2013.
Jolie is asking for physical custody of their six children, Maddox, Pax, Zahara, Shiloh, and twins Knox and Viviennne.
The couple most recently worked together on the 2015 film "By The Sea," on which Jolie also served as writer and director.
A year ago, the couple talked about growing old together.
"As much as we can argue and fight, and we all have our challenges, at the end I say, 'My job is to love him,'" Jolie told People magazine.
"I'm more interested in his 50-year-old self than his 40-year-old-self,” she said. "And then you look forward to even more years together."
Meanwhile, in an interview with The Telegraph, Pitt said, "And I'm surprised how much our history – Angie's and mine – means to me. That we have this story together. That we know each other. That we watch each other getting older, through amazing moments, joys, pains."
"You know, nowadays I really can't wait to get home," he said. "More than at any time in my life, I've got purpose – real purpose. It feels like I've found my place."