More than a dozen people on a Philadelphia-bound flight received medical treatment in Rome, where the plane made an emergency landing early Saturday morning, NBC News reported.
Two passengers and 14 crew members began to feel sick, leading to U.S. Airways flight US797 to make an "unscheduled landing," said Martha Thomas, a spokesman for American Airlines, which merged with U.S. Airways last year.
Reports of an odor in the cabin preceded the landing. All 16 people were treated at a clinic at Rome's Fiumicino Airport and have since been released.
The Airbus A330, which was carrying 129 passengers, 10 flight attendants and four pilots, departed Israel late Friday night.
"The aircraft landed safely and all passengers were re-accommodated on other flights," Thomas said.
An AFP agency report indicated the crew and passengers were suffering from red eyes and nausea.
The airline's maintenance team is evaluating the plane to determine what may have caused the odor, Thomas said.