A fire broke out around 3: 30 a.m. Tuesday morning on the 900 block of Federal Street in South Philadelphia.
When fire crews arrived they found heavy smoke and flames coming from the second floor of the three story row-home.
Firefighters were able to rescue a 67-year-old woman from the blaze.
The victim suffered serious burns to her upper body and is currently listed in critical condition at Jefferson Hospital.
Cold temperatures caused problems with ice forming along Federal Street and a salt truck was needed to melt the ice.
The Philadelphia Fire Marshall continues to investigate what caused the blaze.