"Alice In Wonderland" director Tim Burton was on stage in Hall H at the San Diego Convention Center when he reportedly said he wanted his "imaginary friend" to join him on the stage.
Depp then appeared and the crowd erupted with cheers and screams of joy.
The actor only stayed for a brief moment, waving at the screaming crowd at the Disney 3-D panel.
Depp's appearance flooded Twitter with excited Tweets from inside the crowd.
"Tears wiped over Johnny Depp. Decibel level to 11. This is CRAZY fandom," one user wrote. While another claimed, "Women are chanting 'I love you Johnny!' Men are chanting 'I love you Johnny!!'"
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