ARLINGTON, Texas -- Eli Manning threw for three touchdowns, including the go-ahead score to Victor Cruz in his first game in nearly two years, and the New York Giants beat the Dallas Cowboys 20-19 Sunday.

The Giants (1-0) won the debut of coach Ben McAdoo after 12 years and two Super Bowl titles under Tom Coughlin while spoiling the first game for Dallas' Dak Prescott and Ezekiel Elliott.

Because of Tony Romo's back injury, Prescott and Elliott were the first rookie quarterback-running back combo to start an opener for the Cowboys since Roger Staubach and Calvin Hill in 1969.

The game ended with Dallas in position for a roughly 57-yard field goal, but Terrance Williams didn't get out of bounds after a catch and the clock ran out. Dan Bailey had four field goals, including two from more than 50 yards.

Cruz, who missed most of 2014 with a knee injury and all of last season with a bad calf, broke free in the end zone for a 3-yard TD with 6 minutes remaining, prompting his trademark salsa dance.

Randy Bullock, kicking because of Josh Brown's one-game suspension, made the extra point for the lead after an earlier missed PAT.

New York beat Dallas in an opener for the first time in nine tries.

The Giants' defense, fortified in free agency, held Dallas after the go-ahead score. Then the Giants emphasized the run to use most of the clock, quite a contrast to last season when questionable clock management contributed to six losses late in regulation or in overtime in a 6-10 season.

Elliott was held to a 2.5-yard average (51 yards on 21 carries), although he had his first touchdown, and the only one for Dallas. Prescott was 25 of 45 for 227 yards.

Manning was 19 of 28 for 207 yards, including a 45-yarder to Odell Beckham Jr. set up the first TD (see full recap).

Lions stun Chargers on late field goal
INDIANAPOLIS -- Matthew Stafford took advantage of one last chance Sunday and Matt Prater redeemed himself with a 43-yard field goal with 8 seconds to give the Detroit Lions a 39-35 victory at Indianapolis.

Prater missed an extra point wide right with 4:04 left in the season opener, a miscue that nearly cost the Lions.

Detroit won for only the second time in Indy, and it came just 37 seconds after it looked like Andrew Luck had rallied the Colts for an improbable last-minute victory.

It just wasn't enough to avoid Indy's third straight opening day loss in a wild finish.

After Prater's miss, Luck drove the Colts 75 yards and hooked up with Jack Doyle on a 6-yard TD pass with 37 seconds left. Adam Vinatieri's extra point gave the Colts a 35-34 lead.

This time, Stafford connected with receivers who took advantage of their speed against Indy's thin secondary. He quickly got the Lions into position for Prater to atone for the earlier miss.

Stafford was 31 of 39 for 340 yards with three touchdowns and no interceptions.

Indy was called for a safety on the final play of the game, for throwing an illegal forward pass in its end zone (see full recap).

Chiefs cap off wild comeback by topping Chargers in OT
KANSAS CITY, Mo. -- It took the biggest rally in franchise history for the Kansas City Chiefs to win their opener.

After the Chiefs dug out of a three-touchdown hole, Alex Smith dived for a score on the first possession of overtime Sunday, giving his team a heart-stopping 33-27 win over the San Diego Chargers.

Smith threw for 363 yards and two touchdowns, the second a back-shoulder fade to Jeremy Maclin with just over 9 minutes left in the fourth quarter. The Chiefs, at one point trailing 24-3, had trimmed their deficit to 27-17 and energized a crowd that had begun thinning at halftime.

Cairo Santos kicked a 33-yard field goal a few minutes later. Then, after forcing a three-and-out, Spencer Ware finished a four-play drive with a touchdown plunge to knot the game at 27.

It took Kansas City 10 plays to march 75 yards in overtime. Smith finished it with his keeper on third-and-goal from the 2-yard line as the Chiefs flooded off their bench to celebrate.

Ware finished with 70 yards rushing and had seven catches for 129 yards, giving the Chiefs a big boost without Jamaal Charles. The four-time Pro Bowl running back is still recovering from surgery last season to repair his ACL and was inactive Sunday (see full recap).

Winston tosses 4 touchdowns in Bucs' win over Falcons
ATLANTA -- Jameis Winston is no longer a rookie.

He wasn't about to get flustered when an early mix-up led to an interception.

Bouncing back from that mistake, Winston threw four touchdown passes for the second time in his young career as Tampa Bay claimed a winning record for the first time since 2012 by opening the season with a 31-24 victory over the Atlanta Falcons on Sunday.

Winston began his second year as a pro by going 23 of 33 for 281 yards, using just about every weapon at his disposal in the matchup between NFC South rivals. He hooked up with receiver Mike Evans, running back Charles Sims III and tight ends Austin Sefarian-Jenkins and Brandon Myers on scoring plays (see full recap).

Brees’ 400-yard performance wasted in last-minute loss to Raiders
NEW ORLEANS -- Derek Carr hit Seth Roberts for a 10-yard touchdown with 47 seconds left, then connected with Michael Crabtree on a 2-point conversion, and the Oakland Raiders pulled out a season-opening 35-34 victory over the New Orleans Saints on Sunday.

The Raiders had to overcome a 14-point, second-half deficit and a 424-yard, four-touchdown performance by Drew Brees. They also had to sweat out rookie kicker Wil Lutz's last second field goal attempt from 61 yards, which narrowly missed wide left as the Superdome crowd briefly erupted before realizing the kick was no good.

Brees eclipsed 400 yards passing for the 14th time in his career, tying Peyton Manning for the most such performances in NFL history.

Carr finished with 319 yards and one touchdown passing (see full recap). 

Rodgers, Packers outlast Jaguars
JACKSONVILLE, Fla. -- Aaron Rodgers threw two touchdown passes and ran for another score, leading the Green Bay Packers to a 27-23 victory against the Jacksonville Jaguars in the teams' season opener Sunday.

Rodgers looked every bit like, well, a two-time league MVP. He extended plays with his feet, escaped sacks and had precision accuracy all over the field.

He completed 20 of 34 passes for 199 yards, with TD passes to Jordy Nelson and Davante Adams. He was sacked once for no yards and didn't turn it over.

He helped the Packers win their second opener in the last five years. This one came on a sweltering, late-summer day that left some players cramping and others completely exhausted.

Rodgers had no issues with the heat. More importantly for the Packers: Neither did Nelson, who played his first game in more than a year. Nelson tore the anterior cruciate ligament in his right knee in the 2015 preseason and missed the entire regular season. The injury significantly impacted Rodgers, who lost his best deep threat, and the offense, which fell to 23rd in the league and tied for 25th in passing (see full recap).